The relative importance of particle count, type, and size of ApoB-containing lipoproteins in risk of myocardial infarction

Abstract Background An accumulating body of evidence suggests that the number apolipoprotein B-containing particles (ApoB-P) is more predictive cardiovascular risk than their lipid content. However, it unclear if this association consistent across different lipoprotein types and sizes. Purpose We aimed to evaluate particle type size are associated with incident myocardial infarction (MI) beyond ApoB-P count. Moreover, we determine lipoprotein(a) additive ApoB-P. Methods This prospective cohort study included 96,126 participants without prior history stroke, coronary or peripheral artery disease use lipid-lowering medication from UK Biobank. Count VLDL, IDL, LDL, HDL, as well ApoB level total count were measured in non-fasting plasma samples by nuclear magnetic resonance platform. Lipoprotein(a) was immunoturbidimetric assay. explored associations between these markers MI using Cox proportional hazard models adjusted sequentially for clinical covariates, HDL size, Results Over a median follow-up 12.1 years, 1702 had MI. In unadjusted models, 1-SD increases count, ratio VLDL (LDL+IDL) counts, higher MI, while LDL lower (Table 1). When adjusting covariates parameters, only remained significantly (HR: 1.40 [1.32; 1.48] 1.20 [1.14; 1.27], respectively). Adjusted restricted cubic splines confirmed findings linear trend (Figure highly correlated (r=0.99), replication analyses replacing one another revealed no change results. Conclusion The independently all ApoB-P, not lipoproteins. can be used very accurate surrogate setting. therefore, combination may provide optimal evaluation lipid-mediated risk. Funding Acknowledgement Type funding sources: None.